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In Vivo Visualization of Single Axons and Synaptic Remodeling in Normal and Pathological Conditions


Grillo, FW and Canty, AJ and Bloomfield, P and De Paola, V, In Vivo Visualization of Single Axons and Synaptic Remodeling in Normal and Pathological Conditions, Axons and Brain Architecture, Academic Press, KS Rockland (ed), United States, pp. 223-244. ISBN 978-0-12-801393-9 (2016) [Research Book Chapter]

Copyright Statement

Copyright 2016 Elsevier Inc.

DOI: doi:10.1016/B978-0-12-801393-9.00011-6


Charting the trajectory of individual axons within the intact central nervous system during development into maturity and into the normal aging process has long been the holy grail of neuroimaging. We review a range of approaches that have historically been used to visualize axons, which culminate in the powerful combination of transgenic technologies and microscopy techniques allowing direct observation of axonal dynamics in the intact cerebral cortex. Using animal models of health and disease, the visualization of axons and their connectivity over extended periods of time has become a reality. In this chapter, we review our current knowledge of axonal dynamics in the healthy brain, as well as in a range of neurodevelopmental disorders, neurodegenerative pathologies including dementia, and in response to sensory manipulations and trauma.

Item Details

Item Type:Research Book Chapter
Keywords:aging, axon imaging, axonal injury, axonal pathology, axon development, neurodegenerative disease, neurodevelopmental disease, in vivo imaging, synaptic plasticity, 2-photon imaging, neuroplasticity
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Canty, AJ (Associate Professor Alison Canty)
ID Code:107741
Year Published:2016
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2016-03-22
Last Modified:2017-11-06

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