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Impact of residential medication management reviews on anticholinergic burden in aged care residents


McLarin, PE and Peterson, GM and Curtain, CM and Nishtala, PS and Hannan, PJ and Castelino, RL, Impact of residential medication management reviews on anticholinergic burden in aged care residents, Current medical research and opinion, 32, (1) pp. 123-131. ISSN 0300-7995 (2016) [Refereed Article]

Copyright Statement

Copyright 2015 Taylor & Francis

DOI: doi:10.1185/03007995.2015.1105794


Objectives: The primary objective of this study was to investigate the impact of Residential Medication Management Reviews (RMMRs) on anticholinergic burden quantified by seven anticholinergic risk scales.

Design: Retrospective analysis.

Setting: Accredited pharmacists conducted RMMRs in aged-care facilities (ACFs) in Sydney, Australia.

Participants: RMMRs pertained to 814 residents aged 65 years or older.

Measurements: Anticholinergic burden was quantified using seven scales at baseline, after pharmacists' recommendations and after the actual GP uptake of pharmacists' recommendations. Change in the anticholinergic burden was measured using the Wilcoxon sign rank test.

Results: At baseline, depending on the scale used to estimate the anticholinergic burden, between 36% and 67% of patients were prescribed at least one regular anticholinergic medication (ACM). Anticholinergic burden scores were significantly (p < 0.001) lower after pharmacists’ recommendations as determined by each of the seven scales. The reduction in anticholinergic burden was also significant (p < 0.001) after GPs’ acceptance of the pharmacists’ recommendations according to all scales with the exception of one scale which reached borderline significance (p = 0.052).

Conclusion: Despite the limitations of the retrospective design and differences in the estimation of anticholinergic burden, this is the first study to demonstrate that RMMRs are effective in reducing ACM prescribing in ACF residents, using a range of measures of anticholinergic burden. Future studies should focus on whether a decrease in anticholinergic burden will translate into improvement in clinical outcomes.

Item Details

Item Type:Refereed Article
Keywords:anticholinergic burden, medication reviews, pharmacists, aged-care facilities
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:McLarin, PE (Miss Patricia McLarin)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Curtain, CM (Mr Colin Curtain)
UTAS Author:Castelino, RL (Dr Ronald Castelino)
ID Code:105112
Year Published:2016 (online first 2015)
Web of Science® Times Cited:12
Deposited By:Pharmacy
Deposited On:2015-12-08
Last Modified:2017-11-02

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