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Crystal assembly: The application of high affinity ligands and habit modification

journal contribution
posted on 2023-05-18, 14:21 authored by Blagden, N, Heywood, BR
Streptavidin-biotin was found to induce the aggregation of micrometer-sized calcite particles, and the optimum ligand-receptor surface tagging condition was found when monolayer coverage of the sample by the adsorbed ligand-receptor components was reduced to 80% coverage. The role of crystallography in the agglomeration process induced by the presence of surface-adsorbed ligand-receptor was also examined. This was achieved by using calcite exhibiting three different crystal habits: rhombohedral, hexagonal spindles, and triangular plates. The latter two habits express faces generated by anionic templates, and the topology of agglomerates suggests that the carboxyl group of the biotin and the streptavidin interacting with these surfaces generated a local variation in crystal packing. This was accounted for by simply relating the preferential interaction between the modified surface of the crystal and the high-affinity ligand complex on the functionality of additives used to template surfaces during crystal growth.

History

Publication title

Crystal Growth and Design

Pagination

167-173

ISSN

1528-7483

Publisher

Amer Chemical Soc

Place of publication

1155 16Th St, Nw, Washington, USA, Dc, 20036

Rights statement

© 2003 American Chemical Society

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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