eCite Digital Repository

The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function


Ward, D and Summers, MJ and Saunders, NLJ and Ritchie, K and Summers, JJ and Vickers, JC, The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function, Translational Psychiatry, 5 Article e590. ISSN 2158-3188 (2015) [Refereed Article]


Copyright Statement

Licensed under a Creative Commons Attribution 4.0 International License by/4.0/

DOI: doi:10.1038/tp.2015.82


The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.

Item Details

Item Type:Refereed Article
Keywords:cognitive reserve, ageing, executive function, BDNF
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Ward, D (Mr David Ward)
UTAS Author:Summers, MJ (Dr Mathew Summers)
UTAS Author:Saunders, NLJ (Dr Nichole Saunders)
UTAS Author:Summers, JJ (Professor Jeffery Summers)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:101727
Year Published:2015
Web of Science® Times Cited:15
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2015-07-02
Last Modified:2017-11-06
Downloads:202 View Download Statistics

Repository Staff Only: item control page