The protective roles of microgynon and nordiol in controlling the levels of lipid peroxidation: a comparative study on female rats

Aims: This study aims to evaluate the effects of oral contraception (Microgynon and Nordiol) on the level of lipid peroxidation as a part of oxidative stress progression in female rats. Oral contraception were used.

Materials & Methods: Thirty rats (females) were included in this study. They were divided into 5 groups (six in each group): a control group was maintained on normal standard chow diet, while the other 4 groups received high cholesterol diet for 14 weeks. After 14 weeks, blood samples were taken randomly from 6 rats. The remaining 18 rats were randomly divided into 3 groups (6 rats in each), the first group continued on high cholesterol diet and distilled water for 6 weeks and served as self-control group. The remaining 2 groupscontinued on high cholesterol diet and were given one of the oral contraceptives mentioned above for 6 weeks.

Results: Our data showed that Microgynon treatment resulted in a significant reduction in serum GSH with no significant changes in MDA, CAT and GST activities. However, Nordiol treatment has no significant effects on serum level of GSH, MDA, CAT.

Conclusion: The controversial findings proves the effects of the two types of the oral contraception on lipid peroxidation via different metabolic pathways.