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Arrays of polyacrylamide hydrogels using a carbodiimide-mediated crosslinking reaction
journal contribution
posted on 2023-05-18, 09:21 authored by Sheng, Q, Tian, W, Lapierre, F, Gao, S, Mulder, RJ, Zhu, Y, Kozielski, KA, Wood, CDThis study introduces a radical-free approach for generating polyacrylamide (PAM) hydrogels with no toxic residues remaining in the networks. Acrylamide and bisacrylamide, which are neurotoxins, are not used during the hydrogel synthesis and only nontoxic side products are generated. This is achieved using a gentle carbodiimide-mediated crosslinking (CMCL) reaction that does not require complex initiation systems and is effective in the presence of oxygen. This overcomes some of the key limitations related to PAM hydrogel synthesis using free-radical routes and maintains the advantages of synthetic hydrogels over biopolymers. In addition, the CMCL reaction allows for accurate placement of functional groups, which controls hydrogel structure and performance including mechanical strength, swelling capacity, and hydrophobic balance. This flexibility is demonstrated through the synthesis and rheological characterization of a library of structurally diverse hydrogels as well as spherical hydrogels. PAM-based hydrogels are used extensively in a broad number of applications, and this study demonstrates the applicability of this method as a nontoxic and radical-free complementary alternative route that can generate structures analogous to those prepared using free-radical routes.
History
Publication title
Journal of Applied Polymer ScienceVolume
131Issue
12Article number
40416Number
40416Pagination
1-11ISSN
0021-8995Department/School
School of Natural SciencesPublisher
John Wiley & Sons IncPlace of publication
111 River St, Hoboken, USA, Nj, 07030Rights statement
Copyright 2014 Wiley Periodicals, Inc.Repository Status
- Restricted