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Fucoidan and cancer: a multifunctional molecule with anti-tumor potential

Citation

Atashrazm, F and Lowenthal, RM and Woods, GM and Holloway, AF and Dickinson, JL, Fucoidan and cancer: a multifunctional molecule with anti-tumor potential, Marine Drugs, 13, (4) pp. 2327-2346. ISSN 1660-3397 (2015) [Refereed Article]


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Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/md13042327

Abstract

There is a wide variety of cancer types yet, all share some common cellular and molecular behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to target common deregulated mechanisms within cancer cells. Many healthy tissues are also affected by the cytotoxic effects of these chemical agents. Fucoidan, a natural component of brown seaweed, has anti-cancer activity against various cancer types by targeting key apoptotic molecules. It also has beneficial effects as it can protect against toxicity associated with chemotherapeutic agents and radiation. Thus the synergistic effect of fucoidan with current anti-cancer agents is of considerable interest. This review discusses the mechanisms by which fucoidan retards tumor development, eradicates tumor cells and synergizes with anti-cancer chemotherapeutic agents. Challenges to the development of fucoidan as an anti-cancer agent will also be discussed.

Item Details

Item Type:Refereed Article
Keywords:fucoidan, cancer, apoptosis, synergy
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Oncology and Carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
UTAS Author:Atashrazm, F (Miss Farzaneh Atashrazm)
UTAS Author:Lowenthal, RM (Professor Ray Lowenthal)
UTAS Author:Woods, GM (Professor Gregory Woods)
UTAS Author:Holloway, AF (Associate Professor Adele Holloway)
UTAS Author:Dickinson, JL (Professor Joanne Dickinson)
ID Code:99980
Year Published:2015
Web of Science® Times Cited:118
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-04-22
Last Modified:2017-11-02
Downloads:543 View Download Statistics

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