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Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
Citation
Atashrazm, F and Lowenthal, RM and Woods, GM and Holloway, AF and Dickinson, JL, Fucoidan and cancer: a multifunctional molecule with anti-tumor potential, Marine Drugs, 13, (4) pp. 2327-2346. ISSN 1660-3397 (2015) [Refereed Article]
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Copyright Statement
Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/
Abstract
There is a wide variety of cancer types yet, all share some common cellular and molecular behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to target common deregulated mechanisms within cancer cells. Many healthy tissues are also affected by the cytotoxic effects of these chemical agents. Fucoidan, a natural component of brown seaweed, has anti-cancer activity against various cancer types by targeting key apoptotic molecules. It also has beneficial effects as it can protect against toxicity associated with chemotherapeutic agents and radiation. Thus the synergistic effect of fucoidan with current anti-cancer agents is of considerable interest. This review discusses the mechanisms by which fucoidan retards tumor development, eradicates tumor cells and synergizes with anti-cancer chemotherapeutic agents. Challenges to the development of fucoidan as an anti-cancer agent will also be discussed.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | fucoidan, cancer, apoptosis, synergy |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Oncology and carcinogenesis |
| Research Field: | Oncology and carcinogenesis not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Atashrazm, F (Miss Farzaneh Atashrazm) |
| UTAS Author: | Lowenthal, RM (Professor Ray Lowenthal) |
| UTAS Author: | Woods, GM (Professor Gregory Woods) |
| UTAS Author: | Holloway, AF (Professor Adele Holloway) |
| UTAS Author: | Dickinson, JL (Professor Joanne Dickinson) |
| ID Code: | 99980 |
| Year Published: | 2015 |
| Web of Science® Times Cited: | 173 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2015-04-22 |
| Last Modified: | 2017-11-02 |
| Downloads: | 572 View Download Statistics |
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