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Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype

Citation

Mathey, EK and Park, SB and Hughes, RA and Pollard, JD and Armati, PJ and Barnett, MH and Taylor, BV and Dyck, PJ and Kiernan, MC and Lin, CS-Y, Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype, Journal of Neurology, Neurosurgery and Psychiatry, 86 pp. 973-985. ISSN 0022-3050 (2015) [Refereed Article]


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Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) http://creativecommons.org/licenses/by-nc/4.0/

DOI: doi:10.1136/jnnp-2014-309697

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory neuropathy, classically characterised by a slowly progressive onset and symmetrical, sensorimotor involvement. However, there are many phenotypic variants, suggesting that CIDP may not be a discrete disease entity but rather a spectrum of related conditions. While the abiding theory of CIDP pathogenesis is that cell-mediated and humoral mechanisms act together in an aberrant immune response to cause damage to peripheral nerves, the relative contributions of T cell and autoantibody responses remain largely undefined. In animal models of spontaneous inflammatory neuropathy, T cell responses to defined myelin antigens are responsible. In other human inflammatory neuropathies, there is evidence of antibody responses to Schwann cell, compact myelin or nodal antigens. In this review, the roles of the cellular and humoral immune systems in the pathogenesis of CIDP will be discussed. In time, it is anticipated that delineation of clinical phenotypes and the underlying disease mechanisms might help guide diagnostic and individualised treatment strategies for CIDP.

Item Details

Item Type:Refereed Article
Keywords:myelin, neuroimmunology, neuropathy, neurophysiology, schwann cell
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:Taylor, BV (Professor Bruce Taylor)
ID Code:99888
Year Published:2015
Web of Science® Times Cited:106
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-04-15
Last Modified:2017-11-06
Downloads:451 View Download Statistics

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