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T-box transcription factors and their roles in regulatory hierarchies in the developing heart

Citation

Stennard, FA and Harvey, RP, T-box transcription factors and their roles in regulatory hierarchies in the developing heart, Development (Cambridge), 132, (22) pp. 4897-910. ISSN 0950-1991 (2005) [Substantial Review]


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Abstract

T-box transcription factors are important players in the molecular circuitry that generates lineage diversity and form in the developing embryo. At least seven family members are expressed in the developing mammalian heart, and the human T-box genes TBX1 and TBX5 are mutated in cardiac congenital anomaly syndromes. Here, we review T-box gene function during mammalian heart development in the light of new insights into heart morphogenesis. We see for the first time how hierarchies of transcriptional activation and repression involving multiple T-box factors play out in three-dimensional space to establish the cardiac progenitors fields, to define their subservient lineages, and to generate heart form and function.

Item Details

Item Type:Substantial Review
Keywords:mammalian cardiac development, T-box transcription factor
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Developmental Genetics (incl. Sex Determination)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Stennard, FA (Dr Fiona Stennard)
ID Code:99856
Year Published:2005
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-04-13
Last Modified:2015-04-14
Downloads:0

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