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Voluntary exercise decreases atherosclerosis in nephrectomised ApoE knockout mice
Citation
Shing, CM and Fassett, RG and Peake, JM and Coombes, JS, Voluntary exercise decreases atherosclerosis in nephrectomised ApoE knockout mice, PLoS One, 10, (3) Article e0120287. ISSN 1932-6203 (2015) [Refereed Article]
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Copyright Statement
Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1371/journal.pone.0120287
Abstract
Cardiovascular disease is the main cause of morbidity and mortality in patients with kidney disease. The effectiveness of exercise for cardiovascular disease that is accelerated by the presence of chronic kidney disease remains unknown. The present study utilized apolipoprotein E knockout mice with 5/6 nephrectomy as a model of combined kidney disease and cardiovascular disease to investigate the effect of exercise on aortic plaque formation, vascular function and systemic inflammation. Animals were randomly assigned to nephrectomy or control and then to either voluntary wheel running exercise or sedentary. Following 12-weeks, aortic plaque area was significantly (p < 0.05, d = 1.2) lower in exercising nephrectomised mice compared to sedentary nephrectomised mice. There was a strong, negative correlation between average distance run each week and plaque area in nephrectomised and control mice (r = –0.76, p = 0.048 and r = –0.73, p = 0.062; respectively). In vitro aortic contraction and endothelial-independent and endothelial-dependent relaxation were not influenced by exercise (p > 0.05). Nephrectomy increased IL-6 and TNF-α concentrations compared with control mice (p < 0.001 and p < 0.05, respectively), while levels of IL-10, MCP-1 and MIP-1α were not significantly influenced by nephrectomy or voluntary exercise (p > 0.05). Exercise was an effective non-pharmacologic approach to slow cardiovascular disease in the presence of kidney disease in the apolipoprotein E knockout mouse.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | apoE, kidney disease, inflammation, vascular function |
| Research Division: | Health Sciences |
| Research Group: | Sports science and exercise |
| Research Field: | Sports science and exercise not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Shing, CM (Dr Cecilia Kitic) |
| ID Code: | 99591 |
| Year Published: | 2015 |
| Web of Science® Times Cited: | 13 |
| Deposited By: | Health Sciences |
| Deposited On: | 2015-03-27 |
| Last Modified: | 2017-10-31 |
| Downloads: | 261 View Download Statistics |
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