Sabin, MA and Magnussen, CG and Juonala, M and Shield, JPH and Kahonen, M and Lehtimaki, T and Ronnemaa, T and Koskinen, J and Loo, BM and Knip, M and Hutri-Kahonen, N and Viikari, JSA and Dwyer, T and Raitakari, OT, Insulin and BMI as predictors of adult type 2 diabetes mellitus, Pediatrics, 135, (1) pp. e144-e151. ISSN 0031-4005 (2015) [Refereed Article]
Copyright 2015 by the American Academy of Pediatrics
Background and objectives: Fasting insulin concentrations are increasingly being used as a surrogate for insulin resistance and risk for type 2 diabetes (T2DM), although associations with adult outcomes are unclear. Our objective was to determine whether fasting insulin concentrations in childhood associate with later T2DM.
Methods: Fasting insulin values were available from 2478 participants in the longitudinal Cardiovascular Risk in Young Finns Study at baseline age 3 to 18 years, along with data on adult T2DM (N = 84, mean age = 39.6 years).
Results: Among 3- to 6-year-olds, a 1-SD increase in fasting insulin was associated with a relative risk (RR) of 2.04 (95% confidence interval [CI], 1.54-2.70) for later T2DM, which remained significant after we adjusted for BMI and parental history of T2DM. For those aged 9 to 18 years, a 1-SD increase in insulin was associated with an RR of 1.32 (95% CI, 1.06-1.65) for T2DM, but this became nonsignificant after we adjusted for BMI and parental history of T2DM. In the latter age group, a 1-SD increase in BMI was associated with an RR of 1.45 (95% CI, 1.21-1.73) for T2DM, with adjustment for insulin and parental history of T2DM not improving this association. BMI in younger children was not associated with later T2DM. In life course analyses, those with T2DM had higher fasting insulin levels in early childhood and later adulthood but not in peripubertal years.
Conclusions: Elevated fasting insulin concentrations in early childhood, but not adolescence, are independently associated with an elevated risk of T2DM in adulthood.
|Item Type:||Refereed Article|
|Keywords:||child, insulin, BMI, type 2 diabetes mellitus|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Magnussen, CG (Dr Costan Magnussen)|
|Web of Science® Times Cited:||12|
|Deposited By:||Menzies Institute for Medical Research|
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