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Micropatterned substrates made by polymer bilayer dewetting and collagen nanoscale assembly support endothelial cell adhesion
Citation
Thickett, SC and Moses, J and Gamble, JR and Neto, C, Micropatterned substrates made by polymer bilayer dewetting and collagen nanoscale assembly support endothelial cell adhesion, Soft Matter, 8, (39) pp. 9996-10007. ISSN 1744-683X (2012) [Refereed Article]
Copyright Statement
Copyright 2012 - The Royal Society of Chemistry
Abstract
The ability to control protein and cell positioning on a microscopic scale is crucial in many biomedical
applications, such as tissue engineering and the development of biosensors. We demonstrate here that
the assembly of collagen on patterned surfaces produced by the dewetting of metastable poly(N-vinylpyrrolidone)
(PNVP) films on top of polystyrene films supports the adhesion and survival of a
biologically relevant cell type, human endothelial cells. Micropatterning of Type 1 collagen was
achieved on such substrates by exploiting the different protein affinity of the two polymers, the effect of
treatment with an air plasma, and the control over the nanoscale assembly of collagen using different
adsorption conditions. The simplicity of the dewetting approach, coupled with the ability to coat and
pattern non-planar substrates, gives rise to possible applications in the coating of biological implants
such as arterial stents.
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Chemical Sciences |
Research Group: | Physical chemistry |
Research Field: | Colloid and surface chemistry |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Thickett, SC (Dr Stuart Thickett) |
ID Code: | 99419 |
Year Published: | 2012 |
Web of Science® Times Cited: | 19 |
Deposited By: | Chemistry |
Deposited On: | 2015-03-24 |
Last Modified: | 2017-10-24 |
Downloads: | 0 |
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