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Type I antifreeze proteins enhance ice nucleation above certain concentrations


Wilson, PW and Osterday, KE and Heneghan, AF and Haymet, ADJ, Type I antifreeze proteins enhance ice nucleation above certain concentrations, Journal of Biological Chemistry, 285, (45) pp. 34741-34745. ISSN 0021-9258 (2010) [Refereed Article]


Copyright Statement

Copyright 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

DOI: doi:10.1074/jbc.M110.171983


In this study, we examined the effects that antifreeze proteins have on the supercooling and ice-nucleating abilities of aqueous solutions. Very little information on such nucleation currently exists. Using an automated lag time apparatus and a new analysis, we show several dilution series of Type I antifreeze proteins. Our results indicate that, above a concentration of ∼8 mg/ml, ice nucleation is enhanced rather than hindered. We discuss this unexpected result and present a new hypothesis outlining three components of polar fish blood that we believe affect its solution properties in certain situations.

Item Details

Item Type:Refereed Article
Keywords:blood, glycoprotein, peptide conformation, peptide interactions, plasma, protein chemistry, antifreeze, heterogeneous, ice, nucleation
Research Division:Chemical Sciences
Research Group:Physical chemistry
Research Field:Physical chemistry not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Wilson, PW (Professor Peter Wilson)
ID Code:99249
Year Published:2010
Web of Science® Times Cited:33
Deposited By:Faculty of Health
Deposited On:2015-03-18
Last Modified:2017-11-23
Downloads:116 View Download Statistics

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