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Improvement in strain concordance between two major vendors after the Strain Standardization Initiative


Yang, H and Marwick, TH and Fukuda, N and Oe, H and Saito, M and Thomas, JD and Negishi, K, Improvement in strain concordance between two major vendors after the Strain Standardization Initiative, Journal of the American Society of Echocardiography, 28, (6) pp. 642-648.e7. ISSN 0894-7317 (2015) [Refereed Article]

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Copyright 2015 American Society of Echocardiography

DOI: doi:10.1016/j.echo.2014.12.009


Background: Disagreement of strain measurements among different vendors has provided an obstacle to the clinical use of strain. A joint standardization task force between professional societies and industry was initiated to reduce intervendor variability of strain. Although feedback from this process has been used in software upgrades, little is known about the effects of efforts to improve conformity. The aim of this study was to assess whether intervendor agreement for global longitudinal strain (GLS) has improved after standardization initiatives.

Methods: Eighty-two subjects (mean age, 52 ± 21 years; 55% men) prospectively underwent two sequential examinations using two most common ultrasound systems (Vivid E9 and iE33). GLS was calculated using proprietary software (EchoPAC-PC BT12 [E12] and BT13 [E13] vs QLAB version 8.0 [Q8], QLAB version 9.0 [Q9], and QLAB version 10.0 [Q10]). Agreements in GLS were evaluated with Bland-Altman plots. Coefficients of variation (CVs) were compared using the Friedman test and compared with CVs of left ventricular volumes and ejection fraction (LVEF).

Results: Median GLS using E12 was −19.2% (interquartile range [IQR], −15.2% to −23.2%), compared with −19.3% (IQR, −14.9% to −23.7%) for E13, −15.7% (IQR, −11.4% to −20%) for Q8, −19% (IQR, −15.7% to −22.3%) for Q9, and −18.7% (IQR, −15.7% to −21.7%) for Q10. The CVs of prestandardization GLS (12 ± 8% [E12/Q8] and 14 ± 8 [E13/Q8]) were significantly larger than that of LVEF (5 ± 5) (P < .001). Since standardization, the CVs of GLS have shown improvement (6 ± 4 [E12/Q9], 7 ± 4 [E12/Q10], 6 ± 4 [E13/Q9], and 7 ± 4 [E13/Q10]) and are similar to those of LVEF.

Conclusions: Subsequent to the joint standardization task force, there has been improvement in between-vendor concordance in GLS between two leading ultrasound manufactures, the variability of which is now analogous to that of LVEF. The removal of concerns about measurement variability should allow wider use of GLS.

Item Details

Item Type:Refereed Article
Keywords:strain, ejection fraction, EACVI-ASE strain standardization, concordance, vendor difference
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Yang, H (Ms Hilda Yang)
UTAS Author:Marwick, TH (Professor Tom Marwick)
UTAS Author:Saito, M (Dr Makoto Saito)
UTAS Author:Negishi, K (Dr Kazuaki Negishi)
ID Code:99135
Year Published:2015
Web of Science® Times Cited:98
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-03-14
Last Modified:2017-11-01

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