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Automated electric-field-driven membrane extraction system coupled to liquid chromatography-mass spectrometry

Citation

See, H and Hauser, PC, Automated electric-field-driven membrane extraction system coupled to liquid chromatography-mass spectrometry, Analytical Chemistry, 86, (17) pp. 8665-8670. ISSN 0003-2700 (2014) [Refereed Article]

Copyright Statement

© 2014 American Chemical Society

DOI: doi:10.1021/ac5015589

Abstract

An automated analyte electroextraction and preconcentration system, which was used as the front end for a liquid chromatography–electrospray mass spectrometry instrument, is described. The extraction was based on driving the anionic analytes across a polymer inclusion membrane by application of a potential of 200 V to the cell. Five milliliters (5 mL) of sample were passed through a flow-through cell at a flow rate of 0.2 mL/min containing a membrane 20 μm thick. This consisted of 75% cellulose triacetate as base polymer, 12.5% of tris(2-ethylhexyl)phosphate as plasticizer, and 12.5% of Aliquat 336 as cationic carrier. The target analytes were enriched in 20 μL of a stagnant acceptor solution prior to online LC/MS analysis. The performance of the system was demonstrated for the determination of chlorinated phenoxyacetic acid herbicides in spiked river water. Enrichment factors of ∼200 were achieved with recoveries of typically 99% and precision values of typically 5%. The limit of detection (LOD) values were found to be between 0.03 ng/mL to 0.08 ng/mL.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:See, H (Dr Hong Heng See)
ID Code:99087
Year Published:2014
Web of Science® Times Cited:14
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2015-03-12
Last Modified:2015-04-21
Downloads:0

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