eCite Digital Repository

Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution

Citation

Khalafallah, AA and Ibraheem, AR and Teo, QY and Al Barzan, Abdul-Majeed and Parameswaran, R and Hooper, E and Pavlov, T and Dennis, AE and Hannan, T, Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution, ISRN Obstetrics and Gynecology Article 381826. ISSN 2090-4436 (2014) [Refereed Article]


Preview
PDF
119Kb
  

Copyright Statement

Copyright 2014 Alhossain A. Khalafallah et al. Licenced under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/

DOI: doi:10.1155/2014/381826

Abstract

Pregnancy is a hypercoagulable state associated with an increased risk of venous thromboembolic disease (VTE). We retrospectively studied 38 Caucasian pregnant women with thrombophilia risk and compared their obstetric outcomes with a matched cohort without known thrombophilia risk during the period between January 2007 and December 2010. There were (2) cases with factor V Leiden, (6) prothrombin gene mutation, (1) antithrombin III deficiency, (2) protein C deficiency, (3) protein S deficiency, (10) MTHFR mutation, (7) anti-cardiolipin antibodies, and (1) lupus anticoagulant. Patients without thrombophilia who presented with recurrent unprovoked VTE were considered as high risk (6 cases). Most patients received anticoagulation (34/38) with aspirin only (6), enoxaparin (27), and warfarin (1). Twenty-six out of thirty-eight pregnant women (68.4%) with an increased risk of thrombophilia experienced one or more obstetric complications defined as hypertension, preeclampsia, placenta abruptio, VTE, and oligohydramnios, compared with 15 out of 40 (37.5%) pregnant women in the control group (OR 3.6; 95% CI 1.42, 9.21, P < 0.001). The incidence of obstetric complications was significantly higher in the thrombophilia group compared to the controls. However, these complications were the lowest among patients who received full-dose anticoagulation. Our study suggests that strict application of anticoagulation therapy for thrombophilia of pregnancy is associated with an improved pregnancy outcome.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Paediatrics and Reproductive Medicine
Research Field:Obstetrics and Gynaecology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Reproductive System and Disorders
Author:Khalafallah, AA (Professor Alhossain Khalafallah)
Author:Al Barzan, Abdul-Majeed (Dr Abdul Majeed)
Author:Hannan, T (Dr Terry Hannan)
ID Code:99077
Year Published:2014
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-03-12
Last Modified:2015-04-16
Downloads:143 View Download Statistics

Repository Staff Only: item control page