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Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution
Citation
Khalafallah, AA and Ibraheem, AR and Teo, QY and Al Barzan, Abdul-Majeed and Parameswaran, R and Hooper, E and Pavlov, T and Dennis, AE and Hannan, T, Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution, ISRN Obstetrics and Gynecology Article 381826. ISSN 2090-4436 (2014) [Refereed Article]
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Copyright Statement
Copyright 2014 Alhossain A. Khalafallah et al. Licenced under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/
Abstract
Pregnancy is a hypercoagulable state associated with an increased risk of venous thromboembolic disease (VTE). We retrospectively studied 38 Caucasian pregnant women with thrombophilia risk and compared their obstetric outcomes with a matched cohort without known thrombophilia risk during the period between January 2007 and December 2010. There were (2) cases with factor V Leiden, (6) prothrombin gene mutation, (1) antithrombin III deficiency, (2) protein C deficiency, (3) protein S deficiency, (10) MTHFR mutation, (7) anti-cardiolipin antibodies, and (1) lupus anticoagulant. Patients without thrombophilia who presented with recurrent unprovoked VTE were considered as high risk (6 cases). Most patients received anticoagulation (34/38) with aspirin only (6), enoxaparin (27), and warfarin (1). Twenty-six out of thirty-eight pregnant women (68.4%) with an increased risk of thrombophilia experienced one or more obstetric complications defined as hypertension, preeclampsia, placenta abruptio, VTE, and oligohydramnios, compared with 15 out of 40 (37.5%) pregnant women in the control group (OR 3.6; 95% CI 1.42, 9.21, P < 0.001). The incidence of obstetric complications was significantly higher in the thrombophilia group compared to the controls. However, these complications were the lowest among patients who received full-dose anticoagulation. Our study suggests that strict application of anticoagulation therapy for thrombophilia of pregnancy is associated with an improved pregnancy outcome.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Paediatrics and Reproductive Medicine |
| Research Field: | Obstetrics and Gynaecology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Reproductive System and Disorders |
| Author: | Khalafallah, AA (Professor Alhossain Khalafallah) |
| Author: | Al Barzan, Abdul-Majeed (Dr Abdul Majeed) |
| Author: | Hannan, T (Dr Terry Hannan) |
| ID Code: | 99077 |
| Year Published: | 2014 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2015-03-12 |
| Last Modified: | 2015-04-16 |
| Downloads: | 149 View Download Statistics |
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