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Graded ephrin-A2 expression in the developing hamster superior colliculus

journal contribution
posted on 2023-05-18, 08:22 authored by Lukehurst, SS, Carolyn KingCarolyn King, Beazley, LD, Tay, DKC, So, K-F, Rodger, J
During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostrallow to caudalhigh gradient that is most prominent at postnatal days (P)4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell speciWc markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.

History

Publication title

Experimental Brain Research

Volume

173

Pagination

546-552

ISSN

0014-4819

Department/School

School of Nursing

Publisher

Springer-Verlag

Place of publication

175 Fifth Ave, New York, USA, Ny, 10010

Rights statement

© 2006 Springer-Verlag

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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