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Retinal ganglion cell axons regenerate in the presence of intact sensory fibres


King, AE and Bartlett, C and Sauve, Y and Lund, R and Dunlop, S and Beazley, L, Retinal ganglion cell axons regenerate in the presence of intact sensory fibres, Neuroreport, 17, (2) pp. 195-199. ISSN 0959-4965 (2006) [Refereed Article]

Copyright Statement

2006 Lippincott Williams & Wilkins, Inc.

DOI: doi:10.1097/01.wnr.0000195668.07467.a8


A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adult rat optic nerve. Dorsal root ganglia grafts comprised intact sensory and degenerate motor axons, whereas conventional grafts comprised both degenerating sensory and motor axons. Retinal ganglion cell axons were traced after 2 months. Dorsal root ganglia survived with their axons persisting throughout the graft. Comparable numbers of retinal ganglion cells regenerated axons into both dorsal root ganglia (1053 223) and conventional grafts (1323 881; P > 0.05). The results indicate that an intact sensory environment supports central axon regeneration.

Item Details

Item Type:Refereed Article
Keywords:Retinal ganglion cells, sensory fibres, regeneration
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:King, AE (Professor Anna King)
ID Code:99051
Year Published:2006
Web of Science® Times Cited:2
Deposited By:Health Sciences B
Deposited On:2015-03-11
Last Modified:2015-04-21

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