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Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat
Citation
Rodger, J and Lindsey, KA and Leaver, SG and King, CE and Dunlop, SA and Beazley, LD, Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat, European Journal of Neuroscience, 14, (12) pp. 1929-1936. ISSN 0953-816X (2001) [Refereed Article]
Copyright Statement
Copyright 2001 Federation of European Neuroscience Societies.
DOI: doi:10.1046/j.0953-816x.2001.01822.x
Abstract
The vertebrate retina projects topographically to visual brain centres. In the developing visual system, gradients of ephrins and Eph receptors play a role in defining topography. At maturity, ephrins but not Ephs are downregulated. Here we show that optic nerve section in adult rat differentially regulates the expression of ephrin-A2 in the superior colliculus (SC) and of EphA5 in the retina. Expression was quantified immunohistochemically; ephrin-A2 levels were also estimated by semiquantitative reverse transcriptase polymerase chain reaction. In the normal SC, ephrin-A2 was expressed at low levels. At 1 month, levels of protein and of mRNA were upregulated across the contralateral SC giving rise to an increasing rostro-caudal gradient. At 6 months, levels had fallen but a gradient remained. In the retina of normal animals, EphA5 was expressed as an increasing naso-temporal gradient. By 1 month, expression was decreased in far temporal retina, resulting in a uniform expression across the naso-temporal axis. We suggest that denervation-induced plastic changes within the SC modify expression of these molecules.
Item Details
Item Type: | Refereed Article |
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Keywords: | Eph, ephrin, optic nerve, superior colliculus, topography |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurology and neuromuscular diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | King, CE (Dr Carolyn King) |
ID Code: | 99045 |
Year Published: | 2001 |
Web of Science® Times Cited: | 46 |
Deposited By: | Health Sciences B |
Deposited On: | 2015-03-11 |
Last Modified: | 2015-04-15 |
Downloads: | 0 |
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