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Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish

Citation

King, CE and Wallace, A and Rodger, J and Bartlett, C and Beazley, LD and Dunlop, SA, Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish, Experimental Neurology, 183, (2) pp. 593-599. ISSN 0014-4886 (2003) [Refereed Article]

Copyright Statement

2003 Elsevier Science (USA)

DOI: doi:10.1016/S0014-4886(03)00211-5

Abstract

Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information.

Item Details

Item Type:Refereed Article
Keywords:Eph, ephrin, optic nerve, regeneration, topography
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:King, CE (Dr Carolyn King)
ID Code:99043
Year Published:2003
Web of Science® Times Cited:19
Deposited By:Health Sciences B
Deposited On:2015-03-11
Last Modified:2015-04-21
Downloads:0

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