eCite Digital Repository
Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish
Citation
King, CE and Wallace, A and Rodger, J and Bartlett, C and Beazley, LD and Dunlop, SA, Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish, Experimental Neurology, 183, (2) pp. 593-599. ISSN 0014-4886 (2003) [Refereed Article]
Copyright Statement
© 2003 Elsevier Science (USA)
DOI: doi:10.1016/S0014-4886(03)00211-5
Abstract
Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Eph, ephrin, optic nerve, regeneration, topography |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurology and neuromuscular diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | King, CE (Dr Carolyn King) |
ID Code: | 99043 |
Year Published: | 2003 |
Web of Science® Times Cited: | 22 |
Deposited By: | Health Sciences B |
Deposited On: | 2015-03-11 |
Last Modified: | 2015-04-21 |
Downloads: | 0 |
Repository Staff Only: item control page