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Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transection

Citation

King, CE and Rodger, J and Bartlett, C and Esmaili, T and Dunlop, SA and Beazley, LD, Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transection, Experimental Neurology, 205, (1) pp. 48-55. ISSN 0014-4886 (2007) [Refereed Article]

Copyright Statement

Copyright 2007 Elsevier Inc.

DOI: doi:10.1016/j.expneurol.2007.01.017

Abstract

The cytokine hormone erythropoietin (EPO) is neuroprotective in models of brain injury and disease, and protects retinal ganglion cells (RGC) from cell death after axotomy. Here, we assessed EPO's neuroprotective properties in vivo by examining RGC survival and axon regeneration at 4 weeks following intraorbital optic nerve transection in adult rat. EPO was administered as a single intravitreal injection at the time of transection (5, 10, 25, 50 units, PBS control). Intravitreal EPO (5, 10 units) significantly increased RGC somata and axon survival between the eye and transection site. Twenty five units did not improve survival of RGC somata but did increase axon survival between the eye and transection site. In addition, a small proportion of axons penetrated the transection site and regenerated up to 1 mm into the distal nerve. In a second series, intravitreal EPO (25 units) doubled the number of RGC axons regenerating along a length of peripheral nerve grafted onto the retrobulbar optic nerve. Our in vivo evidence of both neuroregeneration and neuroprotection, taken together with the natural occurrence of EPO within the body and its ability to cross the blood-brain barrier, suggests that it offers promise as a therapeutic agent for central nerve repair.

Item Details

Item Type:Refereed Article
Keywords:Erythropoietin, neuroprotection, neuroregeneration, optic nerve
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:King, CE (Dr Carolyn King)
ID Code:99038
Year Published:2007
Web of Science® Times Cited:73
Deposited By:Health Sciences B
Deposited On:2015-03-11
Last Modified:2015-04-21
Downloads:0

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