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Survival of Indigenous Australians receiving renal replacement therapy: closing the gap?

Citation

Lawton, PD and Cunningham, J and Zhao, Y and Gray, NA and Chatfield, MD and Baade, PD and Murali, K and Jose, MD, Survival of Indigenous Australians receiving renal replacement therapy: closing the gap?, Medical Journal of Australia, 202, (4) pp. 200-204. ISSN 0025-729X (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Medical Journal of Australia

DOI: doi:10.5694/mja14.00664

Abstract

Objectives: To compare mortality rates for Indigenous and non-Indigenous Australians commencing renal replacement therapy (RRT) over time and by categories of remoteness of place of residence.

Design, setting and participants: An observational cohort study of Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) data on Indigenous and non-Indigenous Australians registered with ANZDATA who commenced RRT from 1 January 1995 to 31 December 2009 and were followed until 31 December 2011.

Main outcome measures: Five-year all-cause mortality for Indigenous and non-Indigenous patients in three cohorts (19951999, 20002004 and 20052009) and five remoteness (of place of residence) categories.

Results: Indigenous patients were younger, more likely to have diabetes, be referred late and be from a more remote area than non-Indigenous patients. Age and comorbid conditions increased with successive cohorts for both groups. Unadjusted analysis (using the log-rank test) showed an increased risk of death for Indigenous patients in the 19951999 (P = 0.02) and 20002004 (P = 0.03) cohorts, but not for the 20052009 cohort (P = 0.7). However, a Cox proportional hazards model adjusted for covariates (age, sex, late referral and comorbid conditions [diabetes, coronary artery disease, peripheral vascular disease, cerebrovascular disease, lung disease], and body mass index < 18.5 kg/m2 and > 30 kg/m2) showed the following Indigenous:non-Indigenous hazard ratios (with 95% CIs) for major capital cities: 19951999, 1.47 (1.211.79); 20002004, 1.35 (1.121.63); and 20052009, 1.37 (1.141.66).

Conclusions: Although unadjusted analysis suggests that the survival gap between Indigenous and non-Indigenous patients receiving RRT has closed, there remains a significant disparity in survival after adjusting for the variables considered in our study.

Item Details

Item Type:Refereed Article
Keywords:indigenous, kidney disease, dialysis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Nephrology and Urology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Urogenital System and Disorders
Author:Jose, MD (Professor Matthew Jose)
ID Code:98891
Year Published:2015
Deposited By:Medicine (Discipline)
Deposited On:2015-03-05
Last Modified:2017-11-03
Downloads:0

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