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Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration
Citation
Song, J and Wu, C and Korpos, E and Zhang, X and Agrawal, SM and Wang, Y and Faber, C and Schafers, M and Korner, H and Opdenakker, G and Hallmann, R and Sorokin, L, Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration, Cell Reports, 10, (7) pp. 1040-1054. ISSN 2211-1247 (2015) [Refereed Article]
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Licensed under Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) https://creativecommons.org/licenses/by-nc-nd/3.0/
DOI: doi:10.1016/j.celrep.2015.01.037
Abstract
Although chemokines are sufficient for chemotaxis of various cells, increasing evidence exists for their fine-tuning by selective proteolytic processing. Using a model of immune cell chemotaxis into the CNS (experimental autoimmune encephalomyelitis [EAE]) that permits precise localization of immigrating leukocytes at the blood-brain barrier, we show that, whereas chemokines are required for leukocyte migration into the CNS, additional MMP-2/9 activities specifically at the border of the CNS parenchyma strongly enhance this transmigration process. Cytokines derived from infiltrating leukocytes regulate MMP-2/9 activity at the parenchymal border, which in turn promotes astrocyte secretion of chemokines and differentially modulates the activity of different chemokines at the CNS border, thereby promoting leukocyte migration out of the cuff. Hence, cytokines, chemokines, and cytokine-induced MMP-2/9 activity specifically at the inflammatory border collectively act to accelerate leukocyte chemotaxis across the parenchymal border.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Immunology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Korner, H (Professor Heinrich Korner) |
| ID Code: | 98852 |
| Year Published: | 2015 |
| Web of Science® Times Cited: | 99 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2015-03-04 |
| Last Modified: | 2017-11-06 |
| Downloads: | 283 View Download Statistics |
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