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The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology


Tettey, P and Simpson Jr, S and Taylor, BV and van der Mei, IAF, The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology, Journal of the Neurological Sciences, 348, (1-2) pp. 126-131. ISSN 0022-510X (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.jns.2014.11.019


We reviewed the evidence for the co-occurrence of type 1 diabetes mellitus (T1D) and multiple sclerosis (MS), and assessed the clinical significance of this association and the shared aetiological features of the two diseases. T1D and MS contribute considerably to the burden of autoimmune diseases in young adults. The co-occurrence of MS and T1D has been reported by a number of studies, suggesting that the two conditions share one or more aetiological components. Both conditions have been associated with distinct human leukocyte antigen (HLA) haplotypes but share a number of similarities in clinical, epidemiological and immunological features, leading to suggestions of possible common mechanisms of development. While underlying genetic factors may be important for the co-occurrence of both conditions, some evidence suggests that environmental factors such as vitamin D deficiency may also modulate an individual's risk for the development of both conditions. Evidence on whether the co-occurrence of the two autoimmune conditions will affect the disease course and severity of MS is merely absent. Further studies need to be conducted to ascertain whether the neuropathology associated with T1D might influence the disease course and contribute to the severity of MS.

Item Details

Item Type:Refereed Article
Keywords:autoimmune, comorbidity, latitudinal gradient, multiple sclerosis, type 1 diabetes, ultraviolet radiation and vitamin D
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Tettey, P (Mr Prudence Tettey)
UTAS Author:Simpson Jr, S (Dr Steve Simpson JR)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
UTAS Author:van der Mei, IAF (Professor Ingrid van der Mei)
ID Code:98835
Year Published:2015
Web of Science® Times Cited:27
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-03-04
Last Modified:2017-11-06

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