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The pathophysiological effects of serum copper in type 2 diabetes mellitus with and without diabetic nephropathy


Al-Bayati, MA and Jamil, DA and Al-Aubaidy, HA, The pathophysiological effects of serum copper in type 2 diabetes mellitus with and without diabetic nephropathy, World Journal of Pharmaceutical Research, 4, (1) pp. 178-187. ISSN 2277-7105 (2015) [Refereed Article]

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Copyright 2015 World Journal of Pharmaceutical Research

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This study was undertaken to investigate the effects of copper on the development of lipid peroxidation in patients with type 2 diabetes mellitus with and without diabetic nephropathy. Fifty-five patients with type 2 diabetes mellitus were recruited in this study and were divided into 2 sub-groups based on the presence of microalbuminuria, the first group (microalbuminuric group n = 31) had a microalbuminuria between 30-299 ug/mg. The second group (normoalbuminuric group, n = 29) had an albumin level less than 30 ug/mg. The two diabetic groups were compared to the control group (n = 37). The results of our study showed significant elevation in the levels of serum lipid profiles and lipid peroxidation markers in the microalbuminuric group compared to the normoalbuminuric group at P < 0.001. This was associated with significant rise of serum copper in the diabetic group with nephropathy compared to the diabetic group with no nephropathy and the control group, P < 0.001. The current study illustrates that the presence of microalbuminuria in type 2 DM can be regarded as an index of increased cardiovascular vulnerability and a signal for vigorous efforts at correction of known modifiable risk factors in which serum Cu one of them.

Item Details

Item Type:Refereed Article
Keywords:serum copper, lipid peroxidation, microalbuminuria, type 2 diabetes mellitus
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:98713
Year Published:2015
Deposited By:Medicine
Deposited On:2015-02-26
Last Modified:2016-05-10

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