eCite Digital Repository

Metabolic triggered inflammation in osteoarthritis


Wang, X and Hunter, D and Xu, J and Ding, C, Metabolic triggered inflammation in osteoarthritis, Osteoarthritis and Cartilage, 23, (1) pp. 22-30. ISSN 1063-4584 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2014.10.002


Osteoarthritis (OA) is a common chronic joint disorder with a multifactorial etiology including genetic and environmental factors. Metabolic triggered inflammation, induced by nutrient overload and metabolic surplus, consists of components such as obesity, pro-inflammatory cytokines and adipokines, abnormal metabolites, acute phase proteins, vitamin D deficiency, and deregulated microRNAs that may play a role in OA pathophysiology. Obesity-related metabolic factors, especially adipokines, contribute to OA development by inducing pro-inflammatory cytokines and degradative enzymes, leading to cartilage matrix impairment and subchondral bone remodeling. Ectopic metabolite deposition and low-grade systemic inflammation can contribute to a toxic internal environment that exacerbates OA. Complement components highly expressed in osteoarthritic joints have also been proposed as causative factors. Vitamin D deficiency has been associated with obesity and is implicated to be associated with cartilage loss in OA. Metabolic microRNAs may explain the inflammatory link between obesity and OA. Therapies targeting metabolic-triggered inflammation and its components are anticipated to have potential for the treatment of OA.

Item Details

Item Type:Refereed Article
Keywords:inflammation, metabolic factors, obesity, osteoarthritis
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Wang, X (Ms Xia Wang)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:98708
Year Published:2015
Web of Science® Times Cited:153
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-02-26
Last Modified:2017-11-03

Repository Staff Only: item control page