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Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury


Wang, Q and Song, Y and He, Y and Ren, D and Kow, F and Qiao, Z and Liu, S and Yu, X, Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury, Carbohydrate Polymers, 107 pp. 247-254. ISSN 0144-8617 (2014) [Refereed Article]

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Copyright 2014 Elsevier Ltd. All rights reserved

DOI: doi:10.1016/j.carbpol.2014.02.071


Fucoidan is a well-known natural product that is commonly found in brown algae and shows a variety of activities, including immunomodulation, antioxidation, and the combat of carcinogens. The fucoidan fractions of Costaria costata, a brown algae introduced from Japan and cultured in northern China, were studied. The fucoidan fractions were extracted, separated, and purified using a combinatorial procedure consisting of enzymolysis, ethanol precipitation, and DEAE and size-exclusion chromatographies. The fundamental characteristics of the four enriched fucoidan fractions (F1F4), such as their sulphate content and monosaccharide composition, were investigated. FTIR and NMR spectroscopy were employed to further elucidate the structural features of the four fractions. It was found that the F1F4 fractions all showed oxidative activity against hydroxyl radicals. The bioactive effects of the fucoidan fractions on CCl4-induced liver injury suggest their potential use as ingredients for functional foods or pharmaceuticals.

Item Details

Item Type:Refereed Article
Keywords:fucoidan, Costaria costata, characterisation, liver injury
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Agricultural biotechnology
Research Field:Agricultural marine biotechnology
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Kow, F (Dr Felicia Kow)
ID Code:98628
Year Published:2014
Web of Science® Times Cited:33
Deposited By:IMAS Research and Education Centre
Deposited On:2015-02-22
Last Modified:2015-04-21

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