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Chiral capillary electromigration techniques - mass spectrometry - hope and promise


Wuethrich, A and Haddad, PR and Quirino, JP, Chiral capillary electromigration techniques - mass spectrometry - hope and promise, Electrophoresis, 35, (1) pp. 2-11. ISSN 0173-0835 (2014) [Refereed Article]

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Copyright Statement

Copyright 2014 Wiley-VCH Verlag

DOI: doi:10.1002/elps.201300377


Analytical methods for chiral compounds require a separation step prior to mass spectrometric detection. CE can separate enantiomers by the use of a chiral selector and can be hyphenated with MS. The chiral selector can be either embedded inside the capillary (electrochromatography) or added into the background solution (EKC). This review describes the fundamentals and highlights the recent developments (September 2009-May 2013) of chiral CEC and EKC with detection using MS. There were 20 research and more than 30 review papers during this period. The research efforts were driven by fundamental studies, such as the development of novel chiral selectors in electrochromatography and of advanced partial filling techniques in EKC in order to optimise separation. Other developments were in application studies, such as in food analytics and metabolomics.

Item Details

Item Type:Refereed Article
Keywords:CEC, chiral, EKC, MS
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Wuethrich, A (Mr Alain Wuethrich)
UTAS Author:Haddad, PR (Professor Paul Haddad)
UTAS Author:Quirino, JP (Associate Professor Lito Quirino)
ID Code:98480
Year Published:2014
Web of Science® Times Cited:22
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2015-02-17
Last Modified:2017-10-27

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