Zhang, D and Zhang, L and Zheng, Y and Yue, F and Russell, RD and Zeng, Y, Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients, Diabetes Research and Clinical Practice, 106, (2) pp. 312-318. ISSN 0168-8227 (2014) [Refereed Article]
Copyright 2014 Elsevier Ireland Ltd.
METHODS: 143 newly diagnosed type 2 diabetes patients, 124 patients with impaired glucose tolerance and 121 subjects with normal glucose tolerance were enrolled in this study. Serum zonulin was measured by ELISA.
RESULTS: Patients with type 2 diabetes had higher serum zonulin levels than impaired or normal glucose tolerant subjects. Serum zonulin correlated with body mass index, waist-to-hip ratio, triglyceride, total cholesterol, HDL-C, fasting plasma glucose, 2h plasma glucose, HbA1c, tumor necrosis factor α, interleukin 6, HOMA-IR and QUICK index using correlation analysis (p < 0.05 for all). Multivariate stepwise regression analysis showed that zonulin levels were independently associated with insulin resistance (β = 0.024, p = 0.005). In logistic regression analysis, zonulin levels were an independent predictor of type 2 diabetes (OR = 1.080, p = 0.037).
CONCLUSIONS: Serum zonulin levels are significantly elevated in newly diagnosed Chinese Type 2 diabetes patients, and are associated with dyslipidemia, inflammation and insulin resistance, indicating a potential role of zonulin in the pathophysiology of type 2 diabetes in Chinese.
|Item Type:||Refereed Article|
|Keywords:||Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients.|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Author:||Russell, RD (Dr Ryan Russell)|
|Web of Science® Times Cited:||21|
|Deposited By:||Menzies Institute for Medical Research|
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