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Muscle microvascular blood flow responses in insulin resistance and ageing

Citation

Keske, MA and Premilovac, D and Bradley, EA and Dwyer, RM and Richards, SM and Rattigan, S, Muscle microvascular blood flow responses in insulin resistance and ageing, The Journal of Physiology pp. 1-9. ISSN 1469-7793 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 The Physiological Society

DOI: doi:10.1113/jphysiol.2014.283549

Abstract

Insulin resistance plays a key role in the development of type 2 diabetes. Skeletal muscle is the major storage site for glucose following a meal and as such has a key role in maintenance of blood glucose concentrations. Insulin resistance is characterised by impaired insulin-mediated glucose disposal in skeletal muscle. Multiple mechanisms can contribute to development of muscle insulin resistance and our research has demonstrated an important role for loss of microvascular function within skeletal muscle. We have shown that insulin can enhance blood flow to the microvasculature in muscle thus improving the access of glucose and insulin to the myocytes to augment glucose disposal. Obesity, insulin resistance and ageing are all associated with impaired microvascular responses to insulin in skeletal muscle. Impairments in insulin-mediated microvascular perfusion in muscle can directly cause insulin resistance, and this event can occur early in the aetiology of this condition. Understanding the mechanisms involved in the loss of microvascular function in muscle has the potential to identify novel treatment strategies to prevent or delay progression of insulin resistance and type 2 diabetes.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Keske, MA (Dr Michelle Keske)
Author:Premilovac, D (Dr Dino Premilovac)
Author:Bradley, EA (Miss Eloise Bradley)
Author:Dwyer, RM (Dr Renee Dwyer)
Author:Richards, SM (Dr Stephen Richards)
Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:97966
Year Published:2014
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-01-22
Last Modified:2015-03-10
Downloads:0

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