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Whole genome sequencing: A new paradigm in the surveillance and control of human tuberculosis

Citation

Hasnain, SE and O'Toole, RF and Grover, S, Whole genome sequencing: A new paradigm in the surveillance and control of human tuberculosis, Tuberculosis, 95, (2) pp. 91-94. ISSN 1472-9792 (2015) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier Ltd.

DOI: doi:10.1016/j.tube.2014.12.007

Abstract

Whole Genome Sequencing (WGS) is emerging as a very powerful tool for the management, outbreak analyses, surveillance and determining drug resistance of human infectious pathogens including Mycobacterium tuberculosis and MRSA. WGS can also discriminate relapse TB from re-infection and the resolution provided by WGS has no comparison to conventional technologies. With current cost coming down to <70 per bacterial genome, WGS has emerged as an alternative to all the existing technologies put together. We discuss the advantage and disadvantages of WGS and whether it can become a point of care tool in not just developed countries but also in developing countries which have a huge TB burden. The likely utility of WGS for other pathogens and also in characterizing holobionts is also discussed.

Item Details

Item Type:Refereed Article
Keywords:Mycobacterium, tuberculosis, next generation sequencing
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:O'Toole, RF (Dr Ronan O'Toole)
ID Code:97857
Year Published:2015
Web of Science® Times Cited:5
Deposited By:Medicine (Discipline)
Deposited On:2015-01-16
Last Modified:2016-10-03
Downloads:0

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