eCite Digital Repository

Whole genome sequencing: A new paradigm in the surveillance and control of human tuberculosis


Hasnain, SE and O'Toole, RF and Grover, S, Whole genome sequencing: A new paradigm in the surveillance and control of human tuberculosis, Tuberculosis, 95, (2) pp. 91-94. ISSN 1472-9792 (2015) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier Ltd.

DOI: doi:10.1016/


Whole Genome Sequencing (WGS) is emerging as a very powerful tool for the management, outbreak analyses, surveillance and determining drug resistance of human infectious pathogens including Mycobacterium tuberculosis and MRSA. WGS can also discriminate relapse TB from re-infection and the resolution provided by WGS has no comparison to conventional technologies. With current cost coming down to <70 per bacterial genome, WGS has emerged as an alternative to all the existing technologies put together. We discuss the advantage and disadvantages of WGS and whether it can become a point of care tool in not just developed countries but also in developing countries which have a huge TB burden. The likely utility of WGS for other pathogens and also in characterizing holobionts is also discussed.

Item Details

Item Type:Refereed Article
Keywords:Mycobacterium, tuberculosis, next generation sequencing
Research Division:Biomedical and Clinical Sciences
Research Group:Medical microbiology
Research Field:Medical bacteriology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:O'Toole, RF (Dr Ronan O'Toole)
ID Code:97857
Year Published:2015
Web of Science® Times Cited:19
Deposited By:Medicine
Deposited On:2015-01-16
Last Modified:2017-11-07

Repository Staff Only: item control page