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Whole genome sequencing: A new paradigm in the surveillance and control of human tuberculosis
journal contribution
posted on 2023-05-18, 06:37 authored by Hasnain, SE, O'Toole, RF, Grover, SWhole Genome Sequencing (WGS) is emerging as a very powerful tool for the management, outbreak analyses, surveillance and determining drug resistance of human infectious pathogens including Mycobacterium tuberculosis and MRSA. WGS can also discriminate relapse TB from re-infection and the resolution provided by WGS has no comparison to conventional technologies. With current cost coming down to <£70 per bacterial genome, WGS has emerged as an alternative to all the existing technologies put together. We discuss the advantage and disadvantages of WGS and whether it can become a point of care tool in not just developed countries but also in developing countries which have a huge TB burden. The likely utility of WGS for other pathogens and also in characterizing holobionts is also discussed.
History
Publication title
TuberculosisVolume
95Pagination
91-94ISSN
1472-9792Department/School
Tasmanian School of MedicinePublisher
Churchill LivingstonePlace of publication
Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh, Scotland, Midlothian, Eh1 3AfRights statement
Copyright 2014 Elsevier Ltd.Repository Status
- Restricted