Motion-compensated radiotracer imaging of fully conscious rodents represents an important paradigm shift for preclinical investigations. In such studies, if motion tracking is performed through a transparent enclosure containing the awake animal, light refraction at the interface will introduce errors in stereo pose estimation. We have performed a thorough investigation of how this impacts the accuracy of pose estimates and the resulting motion correction, and developed an efficient method to predict and correct for refraction-based error. The refraction model underlying this study was validated using a state-of-the-art motion tracking system. Refraction-based error was shown to be dependent on tracking marker size, working distance, and interface thickness and tilt. Correcting for refraction error improved the spatial resolution and quantitative accuracy of motion-corrected positron emission tomography images. Since the methods are general, they may also be useful in other contexts where data are corrupted by refraction effects.

Item Type:	Refereed Article
Keywords:	stereo motion tracking, refraction, triangulation, positron emission tomography
Research Division:	Physical Sciences
Research Group:	Other Physical Sciences
Research Field:	Medical Physics
Objective Division:	Health
Objective Group:	Other Health
Objective Field:	Health not elsewhere classified
Author:	Baldock, C (Professor Clive Baldock)
ID Code:	97827
Year Published:	2012
Web of Science® Times Cited:	2
Deposited By:	Office of the School of Engineering
Deposited On:	2015-01-14
Last Modified:	2017-11-06
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