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Refraction-compensated motion tracking of unrestrained small animals in positron emission tomography
Citation
Kyme, A and Meikle, S and Baldock, C and Fulton, R, Refraction-compensated motion tracking of unrestrained small animals in positron emission tomography, Medical Image Analysis, 16, (6) pp. 1317-1328. ISSN 1361-8415 (2012) [Refereed Article]
Copyright Statement
Copyright 2012 Crown Copyright
DOI: doi:10.1016/j.media.2012.04.005
Abstract
Motion-compensated radiotracer imaging of fully conscious rodents represents an important paradigm shift for preclinical investigations. In such studies, if motion tracking is performed through a transparent enclosure containing the awake animal, light refraction at the interface will introduce errors in stereo pose estimation. We have performed a thorough investigation of how this impacts the accuracy of pose estimates and the resulting motion correction, and developed an efficient method to predict and correct for refraction-based error. The refraction model underlying this study was validated using a state-of-the-art motion tracking system. Refraction-based error was shown to be dependent on tracking marker size, working distance, and interface thickness and tilt. Correcting for refraction error improved the spatial resolution and quantitative accuracy of motion-corrected positron emission tomography images. Since the methods are general, they may also be useful in other contexts where data are corrupted by refraction effects.
Item Details
Item Type: | Refereed Article |
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Keywords: | stereo motion tracking, refraction, triangulation, positron emission tomography |
Research Division: | Physical Sciences |
Research Group: | Other Physical Sciences |
Research Field: | Medical Physics |
Objective Division: | Health |
Objective Group: | Other Health |
Objective Field: | Health not elsewhere classified |
Author: | Baldock, C (Professor Clive Baldock) |
ID Code: | 97827 |
Year Published: | 2012 |
Web of Science® Times Cited: | 1 |
Deposited By: | Office of the School of Engineering |
Deposited On: | 2015-01-14 |
Last Modified: | 2017-11-06 |
Downloads: | 0 |
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