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Urinary Pharmacokinetics of Queen Garnet Plum Anthocyanins in Healthy Human Subjects

Citation

Netzel, M and Fanning, K and Netzel, G and Frank, T and Zabaras, D and Russell, D and Stanley, R, Urinary Pharmacokinetics of Queen Garnet Plum Anthocyanins in Healthy Human Subjects, Emerging Trends in Dietary Components for Preventing and Combating Disease, Oxford University Press, BS Patil, GK Jayaprakasha, KN Chidambara Murthy, NP Seeram (ed), United States of America, pp. 375-392. ISBN 9780841226647 (2012) [Research Book Chapter]

DOI: doi:10.1021/bk-2012-1093.ch021

Abstract

A new variety of Prunus salicina, Queen Garnet plum (QGP), was developed as a high anthocyanin, high antioxidant plum, in a Queensland, Australia, Government breeding program. In this manuscript, we are presenting for the first time data about the urinary pharmacokinetics of QGP anthocyanins and derived metabolites in healthy humans. Following consumption of 400 mL QGP juice (QGPJ; 2.49 mmol anthocyanins) by two male subjects, QGP anthocyanins (cyanidin-3-glucoside and cyanidin-3-rutinoside) were excreted mainly as methylated glycosides, glucuronides, and sulfoconjugated metabolites in urine. The cumulative excretion of anthocyanins could be fitted to a one-compartment pharmacokinetic model with instantaneous, parallel excretion of anthocyanin metabolites. The usefulness of this non-linear modeling statistical technique for characterizing the urine excretion-time profiles and estimating relevant PK parameters is demonstrated. Results from this pilot study indicate that methylation and glucuronidation are significant metabolic routes when cyanidin-based anthocyanins are consumed in QGPJ. Future studies investigating the benefits of the consumption of anthocyanin-rich Queen Garnet plums and/or derived products should therefore focus on identifying anthocyanin metabolites and include their putative colonic degradation products. This will assist in evaluating the biological relevance of these compounds to health and disease prevention.

Item Details

Item Type:Research Book Chapter
Research Division:Agricultural and Veterinary Sciences
Research Group:Crop and Pasture Production
Research Field:Crop and Pasture Biochemistry and Physiology
Objective Division:Plant Production and Plant Primary Products
Objective Group:Horticultural Crops
Objective Field:Stone Fruit
Author:Stanley, R (Professor Roger Stanley)
ID Code:97664
Year Published:2012
Deposited By:Tasmanian Institute of Agriculture
Deposited On:2015-01-07
Last Modified:2015-01-07
Downloads:0

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