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Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study

Citation

Wang, X and Blizzard, L and Halliday, A and Han, W and Jin, X and Cicuttini, F and Jones, G and Ding, C, Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study, Annals of The Rheumatic Diseases: The Eular Journal pp. 1-7. ISSN 0003-4967 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 the authors

DOI: doi:10.1136/annrheumdis-2014-206676

Abstract

OBJECTIVE: To describe the cross-sectional and longitudinal associations between knee regional effusion-synovitis and structural changes in older adults.

METHODS: A total of 977 subjects were randomly selected from the local community (mean 62 years, 50% female) at baseline and 404 were followed up 2.6 years later. T2-weighted MRI was used to assess knee effusion-synovitis in four subregions: suprapatellar pouch, central portion, posterior femoral recess and subpopliteal recess. Knee cartilage defects, cartilage volume and bone marrow lesions (BMLs) were measured using MRI at baseline and follow-up.

RESULTS: Cross-sectionally, effusion-synovitis in most subregions was significantly associated with a higher risk of cartilage defects, BMLs and reduced cartilage volume. Longitudinally, suprapatellar pouch effusion-synovitis at baseline predicted an increase in cartilage defects (p<0.01), loss of cartilage volume (p=0.04) and an increase in BMLs (p=0.02) in multivariable analyses. The significant associations of effusion-synovitis with cartilage volume and BMLs disappeared after adjustment for cartilage defects. Effusion-synovitis in whole knee joint (p<0.01) and subpopliteal recess (p<0.05) was consistently associated with longitudinal changes in cartilage defects but not in cartilage volume and BMLs.

CONCLUSIONS: There are independent associations between knee joint effusion-synovitis and knee cartilage defects in both cross-sectional and longitudinal analyses, suggesting a potential causal relationship. The associations of effusion-synovitis with BMLs and cartilage volume were largely dependent on cartilage defects, suggesting potential causal pathways.

Item Details

Item Type:Refereed Article
Keywords:Inflammation; Knee Osteoarthritis; Synovitis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Wang, X (Ms Xia Wang)
Author:Blizzard, L (Associate Professor Leigh Blizzard)
Author:Han, W (Dr Weiyu Han)
Author:Jin, X (Mr Xingzhong Jin)
Author:Jones, G (Professor Graeme Jones)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:97640
Year Published:2014
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-01-06
Last Modified:2015-10-01
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