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Zebrafish - on the move towards ophthalmological research

Citation

Chhetri, J and Jacobson, G and Gueven, N, Zebrafish - on the move towards ophthalmological research, Eye, 28 pp. 367-380. ISSN 0950-222X (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Macmillan Publishers Limited.

DOI: doi:10.1038/eye.2014.19

Abstract

Millions of people are affected by visual impairment and blindness globally, and the prevalence of vision loss is likely to increase as we are living longer. However, many ocular diseases remain poorly controlled due to lack of proper understanding of the pathogenesis and the corresponding lack of effective therapies. Consequently, there is a major need for animal models that closely mirror the human eye pathology and at the same time allow higher-throughput drug screening approaches. In this context, zebrafish as an animal model organism not only address these needs but can in many respects reflect the human situation better than the current rodent models. Over the past decade, zebrafish have become an established model to study a variety of human diseases and are more recently becoming a valuable tool for the study of human ophthalmological disorders. Many human ocular diseases such as cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration have already been modelled in zebrafish. In addition, zebrafish have become an attractive model for pre-clinical drug toxicity testing and are now increasingly used by scientists worldwide for the discovery of novel treatment approaches. This review presents the advantages and uses of zebrafish for ophthalmological research.

Item Details

Item Type:Refereed Article
Keywords:drug development, ocular diseases, retina, vision, visual behaviour, zebrafish
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Pharmacology and Pharmaceutical Sciences not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Chhetri, J (Ms Jamuna Chhetri)
Author:Jacobson, G (Dr Glenn Jacobson)
Author:Gueven, N (Dr Nuri Guven)
ID Code:97545
Year Published:2014
Web of Science® Times Cited:22
Deposited By:Pharmacy
Deposited On:2014-12-22
Last Modified:2015-05-01
Downloads:0

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