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Vitamin D in fetal development: findings from a birth cohort study

Citation

Hart, PH and Lucas, RM and Walsh, JP and Zosky, GR and Whitehouse, AJO and Zhu, K and Allen, KL and Kusel, MM and Anderson, D and Mountain, JA, Vitamin D in fetal development: findings from a birth cohort study, Pediatrics, 135, (1) pp. e167-e173. ISSN 0031-4005 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 by the American Academy of Pediatrics

DOI: doi:10.1542/peds.2014-1860

Abstract

Birth cohort studies provide an invaluable resource for studies of the influence abstract of the fetal environment on health in later life. It is uncertain to what extent maternal vitamin D status influences fetal development. Using an unselected community-based cohort of 901 mother-offspring pairs (the Western Australian Pregnancy Cohort [Raine] Study), we examined the relationship between maternal vitamin D deficiency at 18 weeks’ pregnancy and long-term health outcomes of offspring who were born in Perth, Western Australia (32° South), in 1989–1991. Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] ,50 nmol/L) was present in 36% (323 of 901) of the pregnant women. After adjusting for relevant covariates, maternal vitamin D deficiency during pregnancy was associated with impaired lung development in 6-year-old offspring, neurocognitive difficulties at age 10, increased risk of eating disorders in adolescence, and lower peak bone mass at 20 years. In summary, vitamin D may have an important, multifaceted role in the development of fetal lungs, brain, and bone. Experimental animal studies support an active contribution of vitamin D to organ development. Randomized controlled trials of vitamin D supplementation in pregnant women with long-term follow-up of offspring are urgently required to examine whether the correction of vitamin D deficiency in pregnant women is beneficial for their offspring and to determine the optimal level of maternal serum 25(OH)D for fetal development.

Item Details

Item Type:Refereed Article
Keywords:vitamin D, lung, brain, bone
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Zosky, GR (Associate Professor Graeme Zosky)
ID Code:97397
Year Published:2015
Funding Support:National Health and Medical Research Council (1042235)
Web of Science® Times Cited:29
Deposited By:Medicine (Discipline)
Deposited On:2014-12-16
Last Modified:2016-05-09
Downloads:0

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