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The independent and combined effects of lifetime smoke exposures and asthma as they relate to COPD
Citation
Perret, JL and Walters, EH and Abramson, MJ and McDonald, CF and Dharmage, SC, The independent and combined effects of lifetime smoke exposures and asthma as they relate to COPD, Expert Review of Respiratory Medicine, 8, (4) pp. 503-14. ISSN 1747-6348 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 Informa UK Ltd
DOI: doi:10.1586/17476348.2014.905913
Abstract
Chronic obstructive pulmonary disease (COPD) is part of a worldwide tobacco-related disease epidemic, and is associated with progressive airflow obstruction and varying degrees of emphysema and/or hyperinflation. Greater focus has been placed recently on the potential for early life factors to influence the development of COPD, based on the premise that delayed lung growth during childhood and adolescence might predispose to lung disease in later life. For most people, the adverse effects on lung function of adult and early childhood factors are additive, which provides no additional incentive for current smokers to quit. However, if there is a (synergistic) interaction between active smoking and asthma, smoking cessation is likely to have a greater lung function benefit for the smoker who is also asthmatic, especially if quitting occurs at an early age. This article critically evaluates the evidence for the independent associations of lifetime asthma, smoking and smoke exposures with airflow obstruction, plus their interaction when multiple factors are present.
Item Details
Item Type: | Refereed Article |
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Keywords: | active smoking, asthma, COPD, Interaction, lung function, second-hand smoke, tobacco |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Respiratory diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Walters, EH (Professor Haydn Walters) |
ID Code: | 97363 |
Year Published: | 2014 |
Funding Support: | National Health and Medical Research Council (1021275) |
Web of Science® Times Cited: | 15 |
Deposited By: | Medicine |
Deposited On: | 2014-12-12 |
Last Modified: | 2017-11-03 |
Downloads: | 0 |
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