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Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients
Gresle, MM and Liu, Y and Dagley, LF and Haartsen, J and Pearson, F and Purcell, AW and Laverick, L and Petzold, A and Lucas, RM and Van der Walt, A and Prime, H and Morris, DR and Taylor, BV and Shaw, G and Butzkueven, H, on behalf of the Ausimmune Consortium, Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients, Journal of Neurology, Neurosurgery and Psychiatry, 85, (11) pp. 1209-1213. ISSN 0022-3050 (2014) [Refereed Article]
Copyright 2014 BMJ Publishing Group
METHODS: Serum pNF-H concentrations were measured by ELISA in cases with relapsing-remitting (RR)-MS (n=81), secondary progressive (SP) MS (n=13) and primary progressive (PP)-MS; n=6) MS; first demyelinating event (FDE; n=82); and unaffected controls (n=135). A subset of MS cases (n=45) were re-sampled on one or multiple occasions. The Multiple Sclerosis Severity Score (MSSS) and MRI measures were used to evaluate associations between serum pNF-H status, disease severity and cerebral lesion load and activity.
RESULTS: We confirmed the presence of pNF-H peptides in serum by ELISA. We showed that a high serum pNF-H titre was detectable in 9% of RR-MS and FDE cases, and 38.5% of SP-MS cases. Patients with a high serum pNF-H titre had higher average MSSS scores and T2 lesion volumes than patients with a low serum pNF-H titre. Repeated sampling of a subset of MS cases showed that pNF-H levels can fluctuate over time, likely reflecting temporal dynamics of axonal injury in MS.
CONCLUSIONS: A subset of FDE/MS cases was found to have a high serum pNF-H titre, and this was associated with changes in clinical outcome measures. We propose that routine measurement of serum pNF-H should be further investigated for monitoring axonal injury in MS.
|Item Type:||Refereed Article|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Central nervous system|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Taylor, BV (Professor Bruce Taylor)|
|Web of Science® Times Cited:||27|
|Deposited By:||Menzies Institute for Medical Research|
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