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Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients
journal contribution
posted on 2023-05-18, 05:47 authored by Marathe, CS, Drogemuller, CJ, Marathe, JA, Louavaris, T, Hawthorne, WJ, O'Connell, PJ, Radford, T, Kay, TW, Horowitz, M, Coates, PT, Tropy, DJIslet cell transplantation has emerged as a treatment modality for type 1 diabetes in the last 15 years due to the Edmonton protocol leading to consistent and sustained exogenous insulin independence post-transplantation. In recent years, consortia that involve both local and remote islet cell centers have been established, with local centers responsible for processing and shipping of islet cells, and remote centers only transplanting them. There are, however, few data on patient outcomes at remote centers. A tendency for high fasting glucose despite insulin independence was noted by us and others with an unknown mechanism. This review provides a brief history of islet cell transplantation, and focuses on the South Australian remote center experience: the challenges, screening criteria, and the impact on incretin hormone secretion of insulin independent transplant patients.
History
Publication title
Hormone and Metabolic ResearchISSN
0018-5043Department/School
Tasmanian School of MedicinePublisher
Georg Thieme Verlag KgPlace of publication
Rudigerstr 14, Stuttgart, Germany, D-70469Rights statement
Copyright 2015 Georg Thieme VerlagRepository Status
- Restricted