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Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients

Citation

Marathe, CS and Drogemuller, CJ and Marathe, JA and Louavaris, T and Hawthorne, WJ and O'Connell, PJ and Radford, T and Kay, TW and Horowitz, M and Coates, PT and Tropy, DJ, Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients, Hormone and Metabolic Research ISSN 0018-5043 (2014) [Refereed Article]

Copyright Statement

Copyright 2015 Georg Thieme Verlag

DOI: doi:10.1055/s-0034-1389941

Abstract

Islet cell transplantation has emerged as a treatment modality for type 1 diabetes in the last 15 years due to the Edmonton protocol leading to consistent and sustained exogenous insulin independence post-transplantation. In recent years, consortia that involve both local and remote islet cell centers have been established, with local centers responsible for processing and shipping of islet cells, and remote centers only transplanting them. There are, however, few data on patient outcomes at remote centers. A tendency for high fasting glucose despite insulin independence was noted by us and others with an unknown mechanism. This review provides a brief history of islet cell transplantation, and focuses on the South Australian remote center experience: the challenges, screening criteria, and the impact on incretin hormone secretion of insulin independent transplant patients.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Marathe, JA (Dr Jessica Marathe)
ID Code:97290
Year Published:2014
Web of Science® Times Cited:1
Deposited By:Centre for Rural Health
Deposited On:2014-12-10
Last Modified:2015-08-04
Downloads:0

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