Pan, F and Tian, J and Winzenberg, T and Ding, C and Jones, G, Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects, BMC Musculoskeletal Disorders, 15, (1) Article 404. ISSN 1471-2474 (2014) [Refereed Article]
Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/
METHODS: Searches of Medline, Embase, and ISI Web of Science were conducted up to July 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association between the GDF5 polymorphism and knee OA risk.
RESULTS: A total of 20 studies with 23,995 individuals were included. There were weak but significant associations present between the GDF5 polymorphism and knee OA at the allele level (C vs. T: OR =0.85, 95% CI =0.80-0.90) and genotype level (CC vs. TT: OR =0.73; CT vs. TT: OR =0.84; CC/CT vs. TT: OR =0.81; CC vs.
CT/TT: OR =0.81) in the overall population. In the subgroup analysis by ethnicity, we observed a strong significant association (OR =0.60 to 0.80, all P <0.05) in Asian population and weaker associations (OR =0.78 to 0.87, all P <0.05) in Caucasian population; however marked heterogeneity was detected in all models except for CC vs. TT (I2 = 12.9%) and CC vs. CT + TT (I2 = 0.0%) in Asians.
CONCLUSIONS: These results strongly suggest that the C allele and CC genotype of the GDF5 gene are protective for knee OA susceptibility across different populations.
|Item Type:||Refereed Article|
|Keywords:||GDF5, Polymorphism, Knee, Osteoarthritis, Meta-analysis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Pan, F (Dr Feng Pan)|
|UTAS Author:||Tian, J (Dr Jing Tian)|
|UTAS Author:||Winzenberg, T (Professor Tania Winzenberg)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|Web of Science® Times Cited:||16|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||240 View Download Statistics|
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