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Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects

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Pan, F and Tian, J and Winzenberg, T and Ding, C and Jones, G, Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects, BMC Musculoskeletal Disorders, 15, (1) Article 404. ISSN 1471-2474 (2014) [Refereed Article]


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Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/1471-2474-15-404

Abstract

BACKGROUND: Previous studies investigating the association between GDF5 rs143383 polymorphism and knee osteoarthritis (OA) have suggested stronger associations in Asians than Caucasians, but limitations on the amount of available data have meant that a definitive assessment has not been possible. Given the availability of more recent data, the aim of this meta-analysis was to determine the overall association between GDF5 rs143383 polymorphism and knee OA and whether the association varies by ethnicity.

METHODS: Searches of Medline, Embase, and ISI Web of Science were conducted up to July 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association between the GDF5 polymorphism and knee OA risk.

RESULTS: A total of 20 studies with 23,995 individuals were included. There were weak but significant associations present between the GDF5 polymorphism and knee OA at the allele level (C vs. T: OR =0.85, 95% CI =0.80-0.90) and genotype level (CC vs. TT: OR =0.73; CT vs. TT: OR =0.84; CC/CT vs. TT: OR =0.81; CC vs.

CT/TT: OR =0.81) in the overall population. In the subgroup analysis by ethnicity, we observed a strong significant association (OR =0.60 to 0.80, all P <0.05) in Asian population and weaker associations (OR =0.78 to 0.87, all P <0.05) in Caucasian population; however marked heterogeneity was detected in all models except for CC vs. TT (I2 = 12.9%) and CC vs. CT + TT (I2 = 0.0%) in Asians.

CONCLUSIONS: These results strongly suggest that the C allele and CC genotype of the GDF5 gene are protective for knee OA susceptibility across different populations.

Item Details

Item Type:Refereed Article
Keywords:GDF5, Polymorphism, Knee, Osteoarthritis, Meta-analysis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Pan, F (Mr Feng Pan)
Author:Tian, J (Ms Jing Tian)
Author:Winzenberg, T (Professor Tania Winzenberg)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Jones, G (Professor Graeme Jones)
ID Code:97288
Year Published:2014
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-12-10
Last Modified:2017-11-03
Downloads:168 View Download Statistics

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