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Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments

Citation

Siedler, DG and Chuah, MI and Kirkcaldie, MTK and Vickers, JC and King, AE, Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments, Frontiers in Cellular Neuroscience, 8 Article 429. ISSN 1662-5102 (2014) [Refereed Article]


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Copyright Statement

Copyright 2014 The Authors-Distributed under Creative Commons Attribution License (CC BY 3.0 AU)

Official URL: https://creativecommons.org/licenses/by/3.0/au/dee...

DOI: doi:10.3389/fncel.2014.00429

Abstract

Traumatic brain injury from penetrating or closed forces to the cranium can result in a range of forms of neural damage, which culminate in mortality or impart mild to significant neurological disability. In this regard, diffuse axonal injury is a major neuronal pathophenotype of traumatic brain injury and is associated with a complex set of cytoskeletal changes. The neurofilament triplet proteins are key structural cytoskeletal elements, which may also be important contributors to the tensile strength of axons. This has significant implications with respect to how axons may respond to traumatic brain injury. It is not known, however, whether neurofilament compaction and the cytoskeletal changes that evolve following axonal injury represent a component of a protective mechanism following damage, or whether they serve to augment degeneration and progression to secondary axotomy. Here we review the structure and role of neurofilament proteins in normal neuronal function. We also discuss the processes that characterize diffuse axonal injury and the resultant alterations in neurofilaments, highlighting potential clues to a possible protective or degenerative influence of specific neurofilament alterations within injured neurons. The potential utility of neurofilament assays as biomarkers for axonal injury is also discussed. Insights into the complex alterations in neurofilaments will contribute to future efforts in developing therapeutic strategies to prevent, ameliorate or reverse neuronal degeneration in the CNS following traumatic injury.

Item Details

Item Type:Refereed Article
Keywords:traumatic brain injury, diffuse axonal injury, neurofilament, NFL, diffuse brain trauma, traumatic axonal injury, biomarkers, neurofilament compaction
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Siedler, DG (Mr Declan Siedler)
Author:Chuah, MI (Dr Inn Chuah)
Author:Kirkcaldie, MTK (Dr Matthew Kirkcaldie)
Author:Vickers, JC (Professor James Vickers)
Author:King, AE (Associate Professor Anna King)
ID Code:97174
Year Published:2014
Web of Science® Times Cited:28
Deposited By:Medicine (Discipline)
Deposited On:2014-12-05
Last Modified:2017-11-06
Downloads:90 View Download Statistics

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