eCite Digital Repository

The relationship between CCR6 and its binding partners: Does the CCR6-CCL20 axis have to be extended?


Lee, AYS and Phan, TK and Hulett, MD and Korner, H, The relationship between CCR6 and its binding partners: Does the CCR6-CCL20 axis have to be extended?, Cytokine, 72, (1) pp. 97-101. ISSN 1043-4666 (2015) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.cyto.2014.11.029


Chemokines and their receptors are vital for the trafficking of immune cells. In an orchestrated fashion, up- and down-regulation of chemokines and their receptors contribute to both immune system homeostasis as well as inflammation. The CC chemokine, CCL20 and its cognate receptor, CCR6, are described as one of the few chemokine-receptor pairs that show exclusivity. In our review, we analyze observations which indicate that CCR6 does not have CCL20 as an exclusive ligand as once appreciated. For example, attempts to study the pair, utilizing mainly CCR6-deficient mice, are confounded by a family of non-chemokine ligands known as β-defensins that can bind to CCR6 and potentially can activate the cell. Therefore, a review of the activities of other potential binding partners of CCR6 is essential for interpretation of the current literature on this matter and for an understanding of their involvement in basic immunology and pathology.

Item Details

Item Type:Refereed Article
Keywords:CCR6, defensins
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lee, AYS (Dr Adrian Lee)
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:97170
Year Published:2015
Funding Support:National Health and Medical Research Council (1004592)
Web of Science® Times Cited:29
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-12-04
Last Modified:2017-11-03

Repository Staff Only: item control page