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Use of 'rainy day' autologous haemopoietic stem cells: a single-institution experience over 10 years

Citation

Fox, LC and Ragg, SJ and Lowenthal, RM and Tegg, EM and Johnston, AM, Use of 'rainy day' autologous haemopoietic stem cells: a single-institution experience over 10 years, Internal Medicine Journal, 44, (9) pp. 897-902. ISSN 1444-0903 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 the authors. Internal medicine journal.

DOI: doi:10.1111/imj.12484

Abstract

Background: High-dose chemotherapy and autologous haematopoietic stem cell transplantation is an important therapeutic modality in the treatment of many haematological malignancies. Generally, stem cells are collected close to the time of the transplant, but an alternative is to collect and cryopreserve cells at an early stage of the illness so they are available for later use ('rainy day harvesting'). Although this practice has been commonplace in Australia, there is little evidence to document eventual use of cells collected in this manner.

Methods: We conducted an audit of indications for and eventual transplantation of 'rainy day' harvests performed at our institution over a 10-year period.

Results: Although there was some variation across different disease groups, we found that only 14% of cells were transplanted. The median delay to transplantation was 19 months.

Conclusion: Together with recent advances in stem cell mobilisation techniques, results from this audit suggest that the practice may not be an effective use of limited health resources.

Item Details

Item Type:Refereed Article
Keywords:stem cell transplantation, haematological malignancies, haematopoietic transplantation, autologous transplantation, rainy day
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Ragg, SJ (Dr Scott Ragg)
Author:Lowenthal, RM (Professor Ray Lowenthal)
Author:Tegg, EM (Dr Elizabeth Tegg)
Author:Johnston, AM (Dr Anna Johnston)
ID Code:97130
Year Published:2014
Deposited By:Medicine (Discipline)
Deposited On:2014-12-04
Last Modified:2017-11-01
Downloads:0

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