File(s) under permanent embargo
Use of 'rainy day' autologous haemopoietic stem cells: a single-institution experience over 10 years
journal contribution
posted on 2023-05-18, 05:38 authored by Fox, LC, Scott RaggScott Ragg, Raymond Lowenthal, Tegg, EM, Anna JohnstonAnna JohnstonBackground: High-dose chemotherapy and autologous haematopoietic stem cell transplantation is an important therapeutic modality in the treatment of many haematological malignancies. Generally, stem cells are collected close to the time of the transplant, but an alternative is to collect and cryopreserve cells at an early stage of the illness so they are available for later use ('rainy day harvesting'). Although this practice has been commonplace in Australia, there is little evidence to document eventual use of cells collected in this manner.
Methods: We conducted an audit of indications for and eventual transplantation of 'rainy day' harvests performed at our institution over a 10-year period.
Results: Although there was some variation across different disease groups, we found that only 14% of cells were transplanted. The median delay to transplantation was 19 months.
Conclusion: Together with recent advances in stem cell mobilisation techniques, results from this audit suggest that the practice may not be an effective use of limited health resources.
History
Publication title
Internal Medicine JournalVolume
44Issue
9Pagination
897-902ISSN
1444-0903Department/School
Tasmanian School of MedicinePublisher
Blackwell Publishing AsiaPlace of publication
54 University St, PO Box 378, Carlton, Australia, Victoria, 3053Rights statement
Copyright 2014 the authors. Internal medicine journal.Repository Status
- Restricted