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Disruption of gut integrity may lead to the leakage of gram negative bacteria (lipopolysaccharide, LPS) from the gut into the circulation, a process known as endotoxaemia. LPS is an endotoxin that is harmless when contained within the gut, as the gut normally blocks movement of LPS into the circulation. However, strenuous exercise redirects blood flow away from the gut, increases oxidative stress and results in ischaemia/reperfusion of gastrointestinal tissues, which all act to increase gut permeability and the translocation of LPS across the intestinal wall. Animal models and human trials suggest that probiotics reduce inflammatory exacerbated intestinal permeability. Supplementation with probiotics in athletes has the potential to contribute to improved immune surveillance and maintenance of gut integrity that may be compromised during periods of intense exercise, exercise in hot environments and fluid restriction during exercise. This plenary session will explore the importance of the gut and the potential for probiotics supplementation to enhance exercise performance.

Item Type:	Keynote Presentation
Keywords:	Probiotic; Gut; permeability;
Research Division:	Medical and Health Sciences
Research Group:	Human Movement and Sports Science
Research Field:	Human Movement and Sports Science not elsewhere classified
Objective Division:	Health
Objective Group:	Specific Population Health (excl. Indigenous Health)
Objective Field:	Specific Population Health (excl. Indigenous Health) not elsewhere classified
Author:	Shing, C (Dr Cecilia Kitic)
ID Code:	97106
Year Published:	2013
Deposited By:	Health Sciences A
Deposited On:	2014-12-03
Last Modified:	2014-12-05
Downloads:	3 View Download Statistics