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Postexercise muscle cooling enhances gene expression of PGC-1α

Citation

Ihsan, M and Watson, G and Choo, HC and Lewandowski, P and Papazzo, A and Cameron-Smith, D and Abbiss, CR, Postexercise muscle cooling enhances gene expression of PGC-1α, Medicine and Science in Sports and Exercise, 46, (10) pp. 1900-7. ISSN 0195-9131 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American College of Sports Medicine

DOI: doi:10.1249/MSS.0000000000000308

Abstract

Purpose: This study aimed to investigate the influence of localized muscle cooling on postexercise vascular, metabolic, and mitochondrial-related gene expression.

Methods: Nine physically active males performed 30 min of continuous running at 70% of their maximal aerobic velocity, followed by intermittent running to exhaustion at 100% maximal aerobic velocity. After exercise, subjects immersed one leg in a cold water bath (10C, COLD) to the level of their gluteal fold for 15 min. The contralateral leg remained outside the water bath and served as control (CON). Core body temperature was monitored throughout the experiment, whereas muscle biopsies and muscle temperature (Tm) measurements were obtained from the vastus lateralis before exercise (PRE), immediately postexercise (POST-EX, Tm only), immediately after cooling, and 3 h postexercise (POST-3H).

Results: Exercise significantly increased core body temperature (PRE, 37.1C 0.4C vs POST-EX, 39.3C 0.5C, P < 0.001) and Tm in both CON (PRE, 33.9C 0.7C vs POST-EX, 39.1C 0.5C) and COLD legs (PRE, 34.2C 0.9C vs POST-EX, 39.4C 0.3C), respectively (P < 0.001). After cooling, Tm was significantly lower in COLD (28.9C 2.3C vs 37.0C 0.8C, P < 0.001) whereas PGC-1α messenger RNA expression was significantly higher in COLD at POST-3H (P = 0.014). Significant time effects were evident for changes in vascular endothelial growth factor (P = 0.038) and neuronal nitric oxide synthase (P = 0.019) expression. However, no significant condition effects between COLD and CON were evident for changes in both vascular endothelial growth factor and neuronal nitric oxide synthase expressions.

Conclusions: These data indicate that an acute postexercise cooling intervention enhances the gene expression of PGC-1α and may therefore provide a valuable strategy to enhance exercise-induced mitochondrial biogenesis.

Item Details

Item Type:Refereed Article
Keywords:thermoregulation
Research Division:Medical and Health Sciences
Research Group:Human Movement and Sports Science
Research Field:Exercise Physiology
Objective Division:Health
Objective Group:Health and Support Services
Objective Field:Health and Support Services not elsewhere classified
Author:Watson, G (Dr Greig Watson)
ID Code:97053
Year Published:2014
Web of Science® Times Cited:16
Deposited By:Health Sciences A
Deposited On:2014-12-01
Last Modified:2017-10-31
Downloads:0

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