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Tissue Factor Pathway Inhibitor: Then and Now
Citation
Ellery, PER and Adams, MJ, Tissue Factor Pathway Inhibitor: Then and Now, Seminars in Thrombosis and Hemostasis, 40, (8) pp. 881-886. ISSN 0094-6176 (2014) [Substantial Review]
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DOI: doi:10.1055/s-0034-1395153
Abstract
Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation. TFPI inhibits the TF-activated factor VII (FVIIa) complex in an activated factor X (FXa)-dependent manner, helping to control thrombin generation and ultimately fibrin formation. The importance of TFPI is demonstrated in models of hemophilia where lower levels of FVIII or FIX are insufficient to overcome its inhibitory effect, resulting in a bleeding phenotype. There are two major isoforms in vivo; TFPIα contains three Kunitz-type inhibitory domains (designated K1, K2, and K3), is secreted by endothelial cells and requires protein S to enhance its anticoagulant activity. In contrast, TFPIβ contains only the K1 and K2 domains, but it is attached to the endothelial surface via a glycosylphosphatidylinositol anchor. This review will initially provide a brief history of the major discoveries related to TFPI, and then discuss new insights into the physiology of TFPI, including updates on its association with protein S and FV, as well as the current understanding of its association with disease.
Item Details
Item Type: | Substantial Review |
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Keywords: | TFPI, Haemostasis, Thrombosis, Haemophilia |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Haematology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Diagnosis of human diseases and conditions |
UTAS Author: | Adams, MJ (Dr Murray Adams) |
ID Code: | 97009 |
Year Published: | 2014 |
Web of Science® Times Cited: | 17 |
Deposited By: | Health Sciences A |
Deposited On: | 2014-11-28 |
Last Modified: | 2015-05-12 |
Downloads: | 0 |
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