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Aging and motor inhibition: A converging perspective provided by brain stimulation and imaging approaches
Citation
Levin, O and Fujiyama, H and Boisgontier, MP and Swinnen, SP and Summers, JJ, Aging and motor inhibition: A converging perspective provided by brain stimulation and imaging approaches, Neuroscience and Biobehavioral Reviews, 43 pp. 100-117. ISSN 0149-7634 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 Elsevier
DOI: doi:10.1016/j.neubiorev.2014.04.001
Abstract
The ability to inhibit actions, one of the hallmarks of human motor control, appears to decline with advancing age. Evidence for a link between changes in inhibitory functions and poor motor performance in healthy older adults has recently become available with transcranial magnetic stimulation (TMS). Overall, these studies indicate that the capacity to modulate intracortical (ICI) and interhemispheric (IHI) inhibition is preserved in high-performing older individuals. In contrast, older individuals exhibiting motor slowing and a declined ability to coordinate movement appear to show a reduced capability to modulate GABA-mediated inhibitory processes. As a decline in the integrity of the GABA-ergic inhibitory processes may emerge due to age-related loss of white and gray matter, a promising direction for future research would be to correlate individual differences in structural and/or functional integrity of principal brain networks with observed changes in inhibitory processes within cortico-cortical, interhemispheric, and/or corticospinal pathways. Finally, we underscore the possible links between reduced inhibitory functions and age-related changes in brain activation patterns.
Item Details
Item Type: | Refereed Article |
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Keywords: | aging, compensatory brain activity, coordination, dysfunctional activation spreading, GABA, interhemispheric inhibition, intracortical inhibition, neuroimaging, older adults, performance, reaction time, transcranial magnetic stimulation (TMS) |
Research Division: | Psychology |
Research Group: | Cognitive and computational psychology |
Research Field: | Sensory processes, perception and performance |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in psychology |
UTAS Author: | Fujiyama, H (Dr Hakuei Fujiyama) |
UTAS Author: | Summers, JJ (Professor Jeffery Summers) |
ID Code: | 97008 |
Year Published: | 2014 |
Web of Science® Times Cited: | 94 |
Deposited By: | Psychology |
Deposited On: | 2014-11-28 |
Last Modified: | 2017-11-06 |
Downloads: | 0 |
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