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Sub-cortical infarcts and the risk of falls in older people: combined results of TASCOG and Sydney MAS studies
Citation
Callisaya, ML and Srikanth, VK and Lord, SR and Close, JC and Brodaty, H and Sachdev, PS and Phan, T and Beare, R and Trollor, J and Wen, W and Zheng, JJ and Delbaere, K, Sub-cortical infarcts and the risk of falls in older people: combined results of TASCOG and Sydney MAS studies, International Journal of Stroke, 9, (Suppl A100) pp. 55-60. ISSN 1747-4930 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 International Journal of Stroke
Abstract
AIMS: By pooling data from two Australian population-based studies, we aimed to investigate the association between sub-cortical infarcts and multiple falls and whether this relationship, and that of white matter hyperintensities, is mediated or modified by cognitive or sensorimotor factors.
METHODS: Participants underwent structural magnetic resonance imaging and cognitive and sensorimotor assessments. Falls were prospectively measured over 12 months. Sub-cortical infarcts were detected visually. Total white matter hyperintensity volume was quantified using automated segmentation methods. Generalized linear models were used to examine if sub-cortical infarcts and white matter hyperintensities predicted falls.
RESULTS: The mean age of the sample (n = 655) was 74·5 (standard deviation 6·7) years, 336 (51·3%) males. Overall, 114 (17·4%) had multiple falls. The majority had no sub-cortical infarcts (n = 491, 75·0%), while 90 had one (13·7%), 41 had two (6·3%), and 33 had more than or equal to three sub-cortical infarcts (5·0%). The risk of multiple falls was elevated in people with more than or equal to three sub-cortical infarcts (adjusted relative risk 1·89, 95% confidence interval 1·03, 3·46) and in the highest quarter of white matter hyperintensity volume (adjusted relative risk 1·46, 95% confidence interval 1·00, 2·13). The effect of sub-cortical infarcts on falls was amplified by poorer vision (P = 0·03). The effect of white matter hyperintensities was amplified by poorer vision (P = 0·008), proprioception (P = 0·03), and muscle strength (P = 0·008). There was no modifying effect of cognitive function.
CONCLUSIONS: Increasing burdens of sub-cortical infarcts and white matter hyperintensities are associated with a risk of falling. Interventions targeting sensorimotor factors along with strategies to prevent sub-cortical infarcts and white matter hyperintensities may reduce the risk of falls.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | falls, older people, population based, small vessel disease, sub-cortical infarcts, white matter disease |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Geriatrics and gerontology |
| Objective Division: | Health |
| Objective Group: | Specific population health (excl. Indigenous health) |
| Objective Field: | Health related to ageing |
| UTAS Author: | Callisaya, ML (Dr Michele Callisaya) |
| UTAS Author: | Srikanth, VK (Dr Velandai Srikanth) |
| ID Code: | 96973 |
| Year Published: | 2014 |
| Web of Science® Times Cited: | 8 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2014-11-26 |
| Last Modified: | 2017-11-03 |
| Downloads: | 0 |
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