Verghese, J and Annweiler, C and Ayers, E and Barzilai, N and Beauchet, O and Bennett, DA and Bridenbaugh, SA and Buchman, AS and Callisaya, ML and Camicioli, R and Capistrant, B and Chatterji, S and De Cock, AM and Ferrucci, L and Giladi, N and Guralnik, JM and Hausdorff, JM and Holtzer, R and Kim, KW and Kowal, P and Kressig, RW and Lim, JY and Lord, S and Meguro, K and Montero-Odasso, M and Muir-Hunter, SW and Noone, ML and Rochester, L and Srikanth, V and Wang, C, Motoric cognitive risk syndrome: multicountry prevalence and dementia risk, Neurology, 83, (8) pp. 718-726. ISSN 0028-3878 (2014) [Refereed Article]
Copyright 2014 American Academy of Neurology
METHODS: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini-Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.
RESULTS: At baseline, 2,808 of the 26,802 participants met MCR criteria. Pooled MCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.
CONCLUSION: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.
|Item Type:||Refereed Article|
|Keywords:||dementia, gait, cognition|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Geriatrics and Gerontology|
|Objective Group:||Specific Population Health (excl. Indigenous Health)|
|Objective Field:||Health Related to Ageing|
|Author:||Callisaya, ML (Dr Michele Callisaya)|
|Web of Science® Times Cited:||75|
|Deposited By:||Menzies Institute for Medical Research|
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