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Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy

Citation

Harmer, JA and Keech, AC and Veillard, AS and Skilton, MR and Marwick, TH and Watts, GF and Meredith, IT and Celermajer, DS, for the FIELD Vascular Study Investigators, Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy, Diabetes Research and Clinical Practice, 106, (2) pp. 328-336. ISSN 0168-8227 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier Ireland Ltd

DOI: doi:10.1016/j.diabres.2014.08.029

Abstract

AIM: Impaired arterial function has been implicated in diabetes-related atherosclerosis, but its determinants in high-risk adults have not been well characterised. We investigated factors associated with impaired arterial function in adults with type 2 diabetes.

METHODS: Flow-mediated dilatation (a marker of endothelial function) and dilator response to glyceryl trinitrate (to assess smooth muscle function) of the brachial artery were assessed at baseline in 193 patients with type 2 diabetes from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Traditional risk factors were assessed and a multivariable model was constructed to identify factors independently associated with impaired arterial function.

RESULTS: Median age was 64 years (interquartile range, 58-69; 61% male) and duration of diabetes was 4 years (interquartile range, 2-9). Flow-mediated dilatation (3.06±0.25%, mean±SEM) was severely impaired but not significantly associated with other risk factors. Dilator responses to glyceryl trinitrate (10.56±0.52%) were significantly and independently impaired in past and present cigarette smokers (P=0.005) and in subjects with increased urinary albumin/creatinine ratio (P=0.01).

CONCLUSIONS: In adults with type 2 diabetes and known or suspected atherosclerosis, arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels.

Item Details

Item Type:Refereed Article
Keywords:Arterial function; Atherosclerosis; Flow-mediated dilatation; Glyceryl trinitrate; Smooth muscle cell; Type 2 diabetes mellitus
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Marwick, TH (Professor Tom Marwick)
ID Code:96908
Year Published:2014
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-11-25
Last Modified:2015-04-14
Downloads:0

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